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This algorithm works on all the separate QSAR models

Studies have shown that changes in the gut microbiota down-regulate the expression of tight junction (TJs) proteins, leading to impaired intestinal barrier and bloodbrain barrier function, allowing biomacromolecules and microorganisms to penetrate the barrier, which in turn triggers neuroinflammatory responses (118)

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That's a meaningful distinction when you consider what happens the moment you stop using the drug and blood flow returns to normal

Notably, a reduced abundance of butyrate-producing bacteria triggers inflammatory disorders and increases the risk of colon cancer (Geng et al., 2013