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In fact, rodents lack a human UGT1A4 homologue gene [3]

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To overcome this problem, a Gly-rich linker was inserted between sequences encoding GSH1 or GSH2 and 3XFLAG tag to generate the pF1-GSH1-lin-3XFLAG and pF1-GSH2-lin-3XFLAG constructs

doi: 10.1007/978-1-61779-400-1_2

For most compounds the headline safety question is what are the side effects? For 5-Amino-1MQ the honest headline is we do not yet know, and the correct response to not-knowing is conservatism documented doses, scheduled breaks, and a licensed clinician in the loop rather than assuming the absence of reported effects means the absence of risk