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In addition, the vaccine improved the physical activity of middle-aged mice (50 weeks old) and extended the median lifespan of ZMPSTE24 KO mouse (model of progeria), an extreme model of accelerated aging 62

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Unlike many peptides that degrade rapidly when exposed to gastric acid or enzymatic activity, this sequence demonstrates remarkable resistance to hydrolysis under acidic conditions, a property that has made it an interesting subject for laboratory research and a useful tool for studying peptide stability across a range of experimental conditions