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This is followed by a detailed analysis of the epidemiological links, disease-specific mechanisms, and therapeutic implications for MASLD, ALD, DILI, and HCC

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In contrast, at the pathological levels induced by OS, the highly electrophilic nature of 4-HNE can result in the formation of stable covalent Michael and Schiff base adducts to nucleophilic functional groups of proteins, such as the side chains of cysteine, lysine and histidine