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8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

The peptide conjugate and/or amino acid-comprising conjugation partner, for example a peptide-containing conjugation partner, may comprise one or more solubilising groups

Regarding conversion, we can cite only a manufacturers claim saying that EAC is metabolized in the skin into pure ascorbic acid (and the ascorbic acid content of EAC is very high - 86,4% - compared to the usual 50-60% Vitamin C content of other derivatives)

[DOI] [PubMed] [Google Scholar] 63.Hu J.H., Tian W.Q., Zhao X.L., Zan L.S., Wang H., Li Q.W., Xin Y.P

Front Immunol (2019) 10:1744