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10.1242/dev.00186 21 BergknutN.RutgesJ

GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins

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Increased production and accumulation of A in lysosomes has been observed in autophagy-deficient cells, suggesting that the turnover portion of A is regulated by autophagy