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Melanin Buildup as the Primary Cause Melanin is a pigment produced by the skin as a protective response to external stimuli such as UV rays

doi: 10.1016/j.bjane.2021.08.005

This leads to an increase in regulatory T cells and certain cytokines, including IL-4, IL-5, IL-10, IL-13 and TGF- (Ayelign et al .,

On the other hand, goat milk with or without fed with linseed (to enriched with omega-3 fatty acids) fermented with Lacticaseibacillus paracasei Shirota or Lacticaseibacillus rhamnosus A2 and Lacticaseibacillus paracasei FS109 showed high number of viable probiotic organism during storage (38)

457 showed that pHLIP-Ku80 (), which was created by covalently conjugating pHLIPs with PNA targeting KU80 via disulfide bonds, could selectively reduce Ku80 expression under acidic conditions