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Rapid restoration of cognition in Alzheimers transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

For example, two post mortem studies reported lower GSH in temporal and cerebellar regions in ASD [8,9], therefore GSH differences in ASD may well be brain-region specific

At a 10 mg/mL concentration, 5 units delivers only 0.5 mg, which is one-tenth of the intended dose

Furthermore, long-term studies with extended observation periods, doseresponse profiling, and pharmacokinetic evaluation will be necessary to establish optimal dosing regimens and assess clinical safety