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This efficacy limitation, rather than safety concerns, halted further development

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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Risks and Complications Vitamin B12 deficiency during pregnancy can pose many risks and complications for both the mom and her baby (7)