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doi: 10.1073/pnas.1611776114 70 NzizaNCizmeciDDaviesLIrvineEBJungWFendersonBAet al

Both receptors have been reported in neonatal foreskin-derived keratinocytes with estradiol specifically upregulating ER [71]

10.1039/c4ra09470k 104 LinW.XuY.HuangC.-C.MaY.ShannonK

Cellular senescence is a state in which cells permanently exit the cell cycle but resist apoptosis (programmed cell death), accumulating in tissues with age and secreting a cocktail of inflammatory factors known as the senescence-associated secretory phenotype (SASP)