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The expression of the Parkinsons disease-related gene Parkin contributes to the network of sulfhydryl groups available in the cell, including glutathionylation, which involves reversible post-translational modifications of selected cysteine residues (El et al., 2023)

free cysteine residues, are capable of reacting with the maleimide moiety

By contrast, drugs that target metabolic pathways (e.g., GLUT1 inhibitors, PPP inhibitors, PDK inhibitors, and glutaminase inhibitors) may provide promising efficacy in ovarian cancer cells harboring nutrient addiction