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The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

[112] investigated whether there was a correlation between C677T polymorphism, birth weight, and the risk of developing CVD in 113 morbidly obese French adolescents (BMI = 39.1 6.4 kg/m 2 ) at the age of 14.4 1.5 years

This results in joint pain, deformity, and disability (Yoo et al., 2009)

It accelerates degradation

Since tumor cells with certain oncogenic mutations are very sensitive to ferroptosis, triggering ferroptosis may also have significant therapeutic potential for ferroptosis-sensitive tumor cells ( c /GSH/GPX4 axis have been shown to be fatal in host cells