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Mixing an approved drug with an investigational compound is the standard safety position

In a recent interventional study, 80 first-episode drug-naive patients with BD who received psychotropic therapy supplemented with either probiotic or placebo were followed up for 3 months for observing clinical symptom improvements and changes in oxidative stress markers [305]

Nevertheless, whether it is chemotherapy, targeted therapy or immunotherapy, there exists widespread drug resistance, which can hinder the treatment of tumours and cause disease recurrence (2)