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Topical vitamin C is an antioxidant

doi: 10.1111/jcmm.12399 33 WuHShengZ-QXieJLiRChenLLiG-Net al

The oxygenation of the crystalloid or colloid organ preservation solution, commonly applied in clinical practice, supplies dissolved oxygen that may only satisfy the metabolic requirements of the grafts during HMP and SNMP at temperatures below 20C (141)

Under irradiation, IGFBP-3 induces apoptosis and ROS production by activating NF-B signaling and ROS further promote IGFBP-3 mediated signaling activity