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237 mTORC2 also regulates mitochondrial dynamics (Fig

This type is often associated with thinning of the skin in the periorbital region, collagen loss and fat depletion due to aging

Zulazmi et al

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The term inflamm-aging is used to describe this age-related immune phenotype of inflammation, characterized by a chronic, low-grade pro-inflammatory state, which is related to both activation of the innate immune system and continued exposure to antigens and stress ( Increased cell ageing and exposure to endogenous infectious agents and harmful signals throughout life imbalance the innate and adaptive immune responses, shifting toward greater involvement of innate immune cells, to the detriment of adaptive immunity based on antigen response ( With ageing, there is an alteration of the adaptive immune response affecting T and B lymphocytes, decreasing the ability to respond to antigens (Roubenoff et al., 1998