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The GCLC floxed mice (Cre-negative) shows lowered levels of glutathione in blood probably because introduced loxp sequences interrupt GCLC expression (Fig

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Arch Biochem biophysics

Alcohol consumption may also affect glutathione levels in the body

Another limitation to the study is the use of subjective and informant-based instruments (SRS, ABC, SEC, CGI) due to the lack of reliable and readily available objective or performance-based instruments to measure the clinical severity of ASD and treatment outcomes

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