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Nat Rev Drug Discov 3(1):1726 Wang N, Yu H, Song Q et al (2021) Sesamol-loaded stearic acid-chitosan nanomicelles mitigate the oxidative stress-stimulated apoptosis and induction of pro-inflammatory cytokines in motor neuronal of the spinal cord through NF-B signaling pathway

It is associated in published preclinical literature with collagen and decorin regulation and broad gene-expression shifts in ECM-related markers

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Additionally, non-pharmacological interventions such as cognitive training, cognitive behavioural therapy, and art or light therapy, previously deemed exotic, are now beginning to be integrated into therapeutic guidelines