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doi: 10.3389/fmed.2023.1302352 51

The Mitochondrial Multiplication Mechanism PQQ demonstrates the unique ability to stimulate the creation of new mitochondria through activation of PGC-1 , the master regulator of mitochondrial biogenesis

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This discovery has proven critical in the development of pharmaceutical interventions against obesity

By restoring redox homeostasis and scavenging excessive ROS levels, NRF2 has become an attractive target to prevent and/or ameliorate several diseases associated with oxidative stress