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During the initial phases of apoptosis, phosphatidylserine (PS) residues translocate from the inner to the outer-leaflet of the plasma membrane

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Consistent with prior studies 4,24 , ACLY KO cells maintain lower levels of histone acetylation at H3K23 and H3K14 than their WT and ACSS2 KO counterparts, and DKO cells exhibit similar levels of acetylation as single ACLY KO cells (Figure 4A, B)