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Administration of OTX015 could diminish the phenotype of CSCs, providing a compelling strategy in the most aggressive PC [118]

In preclinical models, it reduces plasma homocysteine and methionine levels without adverse events (83)

Hu J, Zhang Q, Ren X, Sun Z, Quan Q

Highest purity fractions were concentrated, aliquoted and frozen at 80 C

Briefly, the following day, cells were treated with DCFH-DA at 20 M for 45 min and then washed, and then treated with the indicated conditions for 4 h