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doi:10.1016/j.neurobiolaging.2015.03.015 pmid:25983062 Jin SM, Youle R (2013) The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

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This process requires meticulous surveillance of adverse events throughout clinical trials and comprehensive safety verification for each individual strain (563)