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Species of the Ajuga plant have been traditionally used as remedies for high BP in East and North Africa (164)

Testing for MTHFR variants is done for several purposes: Homocysteine Levels and Cardiovascular Risk : Variants in the MTHFR gene can lead to elevated homocysteine levels, a known risk factor for cardiovascular diseases such as heart attack and stroke

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The imbalance of gut microbiota, such as the decrease of Bifidobacterium and Lactobacillus, and the increase of pathogenic bacteria, can stimulate the secretion of pro-inflammatory cytokines by increasing the intestinal epithelial permeability, while Lactobacillus and Bifidobacterium can down-regulate the secretion of pro-inflammatory cytokines

An imbalance between the oxidant formation and the antioxidant capacity in favor of the former causes oxidative stress