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Intended for laboratory and research applications

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This is usually less than 1.5 milliliters (mL), but up to 3 mL may be administered into the abdomen

Potential mechanisms for this interaction include (1) cooperation between germline and somatic variants in different pathways to promote a clonal advantage 318 , (2) germline variants acting downstream of somatic variants to modulate clonal advantage (and vice versa), (3) germline variants promoting the formation of larger-scale somatic events such as chromosomal abnormalities 177 , and (4) germline variants (for example, in DNA repair pathways) contributing to clonal advantage, agnostic to the nature of the somatic mutation driving the clone