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This disorder is associated with mitochondrial abnormalities of respiratory function, Ca 2+ cycling, ROS/RNS production, mPTP opening, activation of different mechanisms of programmed cell death, disbalance of the processes of mitochondrial fusion, fission, and autophagy, and disturbances in synaptogenesis and synaptic transmission which affect the brain development and cause behavioral deficits

It may be explained by several factors: DO 2 -VO 2 dependency, the effect of oral water on gut oxygen balance, or body thermogenesis following water ingestion ( 2 that can be diminished by decreasing the amount of enteral nutrition ( b -adrenergic stimulation, as observed with intravenous infusion of epinephrine ( Clinical Implication The present results demonstrated the effectiveness of oral water to improve blood flow and tissue perfusion

53 These investigators noted endothelial damage with thrombus formation within 1 hour of injection, with ultimate conversion into a fibrous cord within 2 to 4 weeks

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