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Human induced pluripotent [37, 38] or hematopoietic [39, 40] stem cell-based models overcome the translational problems related to the BBB

(The situation was very similar to that of Anschluss in Austria in 1938 though the conclusion was not the same)

Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, et al

While the present studies reveal important aspects of l-carnitine metabolism in humans and illuminate the intermediary involvement of BB in TMAO generation from dietary l-carnitine, multiple important questions remain before we can exploit this newfound knowledge to develop therapeutic interventions that target this pathway

We therefore suggest for future studies on monothiol mechanism (i) to take the bulkiness of the putative Grx(SSR) intermediate, an S N 2 reaction geometry, and a possible accumulation of Grx(SSR) as an artifact into account (Fig