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11 Solid evidence on the safety of parenteral, lifelong, high dose hydroxocobalamin is available from decades of treating patients with inborn errors of B 12 metabolism (eg, cobalamin C deficiency)

Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)

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Frequently Asked Questions Do B12 shots help you lose weight