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and accelerated matrix remodeling through coordinated MMP activity and collagen deposition

First, GLP-1RAs have been shown to inhibit the expression and release of proinflammatory cytokines, such as IL-6 and TNF-, thereby inhibiting the overall inflammatory response

A total of 177 natural products with greater potential for AD treatment were screened by mapping the target gene set of each natural product to the constructed network, yielding 177, 103, and 29 natural products from Most Studied Pathways, Gene-Associated Pathways, and Popular Pathways, respectively (Additional file 1: Table S7)

[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Bryant A.E., Aldape M.J., Bayer C.R., Katahira E.J., Bond L., Nicora C.D., Fillmore T.L., Clauss T.R., Metz T.O., Webb-Robertson B.-J., et al