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Virtual screening of FDA-approved drugs against triose phosphate isomerase from entamoeba histolytica and Giardia lamblia identifies inhibitors of their trophozoite growth phase

Among them, mucin 2 (MUC2) secreted by goblet cells constitutes the mucus layer covering the intestinal epithelium, which not only prevents mechanical injuries and harmful substances at the physical level but also neutralizes or defends against pathogens and toxins in the intestinal lumen through the function of the chemical barrier, thus playing a crucial role in the intestinal barrier

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It was suggested that Sal A enhanced GSH synthesis due to its activatory effect on CBS and consequent homocysteine conversion to cysteine, which subsequently enhanced antioxidant defence and prevented redox-induced GSH loss, leading to further increase in GSH pool size and GSH/GSSG ratio in hyperlipidemic rats

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