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However, no large-scale human clinical trials have been completed, so long-term safety data in humans remains limited

However, its legal compounding for patient use was prohibited under the 2023 Category 2 designation

Quinonez-Silvero C, Hubner K, Herzog W

Dosage and administration Typical protocols in the literature and clinical practice use subcutaneous injection , often run in a loading-then-maintenance pattern: a higher loading dose over the first 46 weeks, then a lower maintenance dose

What makes them noteworthy is the novelty of their targets: Dihexa works through the hepatocyte growth factor (HGF) / c-Met receptor system, while PE-22-28 blocks TREK-1 two-pore domain potassium channels