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Microbial enzymes convert primary bile acids into secondary derivatives that enter systemic circulation, with trace amounts reaching the CNS to regulate glial functions through dedicated receptors (Mertens et al., 2017)

*Correspondence: Abubakar Bello, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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