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Acknowledgements We thank Elisabeth Rushing (Institute of Neuropathology, University Hospital Zurich) for support with the analysis of histological sections and Friedhelm Bladt and Frank Jhrling (Merck, Darmstadt, Germany) for providing EMD1214063 and for helpful discussions

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[1] Mechanistically it works along a single hormonal pathway the amylin system which is what distinguishes it from the multi-receptor incretin agonists it is often compared with