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Pharmacol Res 113:257264

Success requires matching peptide mechanisms to disease pathology, using adequate doses achieving receptor engagement, maintaining treatment long enough for effects manifesting, combining complementary mechanisms for complex diseases, and monitoring mechanism-relevant outcomes documenting engagement

doi: 10.1016/j.lungcan.2004.05.016 114 OrlandoLRenneGRoccaACuriglianoGColleoniMSeveriGet al

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[5,6] Additionally, the alpha 1-adrenergic receptor, located in the pineal gland, has emerged as a potential target in DSIP-related research