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376 Similar to systemic IR, brain IR can be defined as failed response to insulin by brain cells, 377,378 primarily due to downregulated insulin receptors, an inability of insulin receptors to bind insulin, or dysfunction of the insulin signaling cascade

And just to keep things relatively sane, a little science

However, accurate, efficient and selective identification, separation and quantification of exocrine remains a challenge (48)

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The somatotropic axis in human aging: framework for the current state of knowledge and future research