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Suppression of ODC1 activity appears to redirect ornithine metabolism toward urea production rather than putrescine, and because urea can be efficiently eliminated from astrocytes via the bloodstream and excreted in urine, no adverse effects were observed under the reported treatment regimen

The successful wet-laboratory experiment was thus the proof of concept of the model (Gajdanowicz et al., Reference Gajdanowicz, Michard, Sandmann, Rocha, Corra, Ramrez-Aguilar, Gomez-Porras, Gonzlez, Thibaud, van Dongen and Dreyer2011

Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity

Notably, we have demonstrated NAC to be efficacious in reducing the sequelae of mTBI in a randomized, double-blind, placebo-controlled study examining mTBI after blast injury [37]