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Low Grade Dysplasia If biopsies are found to have low-grade dysplasia ( Image 4 and Figure 6 ), where the nuclei are still small but somewhat disorganized, several things should happen: First, the doctor should have a second pathologist also look at your biopsies, because low-grade dysplasia can be a hard diagnosis for a pathologist to make correctly, and sometimes there is disagreement among pathologists that might require yet another opinion to resolve