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In detail, these authors retrospectively evaluated the electronic health record database of PsO patients to assess the risk of incident inflammatory arthritis after initiation of biological therapies over a mean time span of 2.4 years, finding the risk of developing inflammatory arthritis to be significantly lower in patients under treatment with IL12/23 inhibitors (adjusted HR 0.58, 95% CI 0.430.76) or IL-23 inhibitors (0.41, 0.170.95) compared to patients treated with TNF inhibitors, while no significant difference was observed between IL-17 inhibitors (0.86, 0.541.38) and TNF inhibitors

For estimated changes for selected procedures, we refer readers to Table 168

Generally, after 812 weeks of continuous use, a 4-week washout period is required to avoid tolerance from long-term continuous use

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