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NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability

Long-term human safety data does not exist

You may wish to ask your GP the following questions: Has my B12 level been checked recently , particularly if I have been on metformin for more than a year, or if I have symptoms or risk factors for deficiency

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use