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[] Additionally, catalytically active GTP hydrolysis is absolutely necessary, as GTPase-deficient OPA1 mutants are unable to support fusion

Hypertrophic adipose tissue is associated with immune cell recruitment, increased basal fatty acid release, pro-inflammatory cytokine release, hypoxia, necrotic-like abnormalities, fibrosis, decreased adiponectin, impaired insulin sensitivity, and insulin-dependent glucose uptake related to a defect in GLUT4 trafficking (Choe et al., 2016)

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Ideal candidates often include people who have already tried conservative treatments such as physical therapy, stretching routines, or over-the-counter anti-inflammatories (like NSAIDs) without lasting relief