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Also, hyperactivation of the hypothalamus-pituitary-adrenal axis, altered metabolic clearance of cortisol, coupled with changes in corticosteroid-binding globulin and corticosteroid receptor sensitivity may contribute to increasing cortisol availability [79, 84,85,86,87,88,89] Together, these processes create a state of tissue-specific cortisol excess, promoting visceral adiposity, insulin resistance, and metabolic dysfunction [79, 84,85,86,87,88,89] It is however noteworthy that the relationship between cortisol levels and obesity are inconsistent, as some investigators have documented positive, null, or even inverse associations, likely reflecting complexities in glucocorticoid production, variable cortisol clearance, and metabolic regulation [84, 90,91,92,93,94,95]

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In this study, we present robust validation methodology and assess generalization capabilities of an outcome prediction model for ischemic stroke

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In addition, implementing environmental strategies like using air purifiers, dehumidifiers, and cleaning with mold-fighting solutions can help maintain a mold-free environment