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280 In addition, ROS exacerbates airway inflammation by activating inflammatory mediators and transcription factors, such as NF-B, MAPK and AP-1

For example, at a high m , the mitochondrial respiratory chain promotes a significant production of reactive oxygen species (ROS), which have an exponential dependence (Yaniv et al., 2010

These data from the Nf1 Prx1 -/- mice suggest that any future trials for L-carnitine treatment of NF1 muscle could also include a DEXA arm to assess any benefits on bone health