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Physiologically, patients with asthma frequently experience disruptions in their melatonin levels, namely a delayed acrophase in peak serum concentrations, as well as in the amount of GSH produced in the lung ( In clinical practice, melatonin is often prescribed at a dose of 2mg for the average (70kg) human adult (69)

TABLE 1 Summary of RDP human clinical studies on Pycnogenol sorted by applications and by year of publication