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These include Crohn's disease affecting the terminal ileum, coeliac disease, previous gastric or ileal surgery, and pancreatic insufficiency

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However: human metabolic effects remain largely unconfirmed

Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial

In non-T cells, IGF-1 has also been described as cytoprotective, given its ability to preserve mitochondrial function and biogenesis 23,24,25 , but this has yet to be studied in T cells