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The simple and most accurate answer is: Yes, it absolutely can, but only if your fatigue is caused by a B12 deficiency

Mller TD, Sullivan LM, Habegger K, Yi C-X, Kabra D, Grant E, et al

Parsons RB, Aravindan S, Kadampeswaran A, Evans EA, Sandhu KK, Levy ER, Thomas MG, Austen BM, Ramsden DB (2011) The expression of nicotinamide N -methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of complex I inhibitors

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