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Acknowledgements The authors wish to acknowledge Humphrey Chukwudi Omeoga, of Thomas BegLey Laboratory, Department of Biological Sciences, State University of New York, at Albany, New York USA for using his licensed accessed BioRender for the diagrams sketching

In addition, the titration of dietary Mn not only tailors the control of circulating lipids in animals but can also significantly revere atherosclerotic plaques, highlighting a potential therapy for treating these potentially deadly cardiovascular lesions 137,138