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Targeting mitochondrial dysfunction and oxidative stress in activated microglia using dendrimer-based therapeutics

In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

The correct CPT code depends on whether the patient is new or established and on the medical decision-making complexity of the encounter

When compared to the vehicle control, transcranial application of P2RY12 or P2RX4 receptor antagonists impeded the ability of microglia (green) to assume both honeycomb and jellyfish morphologies, whereas P2RY6 antagonism blocked the formation of jellyfish processes only

doi:10.1371/journal.pone.0157389 Patibandla S, Heaton J, Kyaw H