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doi: 10.3390/cancers12082197

Varied Results: Effectiveness varies from one individual to another due to genetics, dosage, and formulation (oral, topical, or injectable)

Additionally, certain variants in genes related to antioxidant response, such as the catalase (CAT) gene and the glutathione peroxidase (GPX) gene, have been associated with increased susceptibility to vitiligo.67,69,70 Furthermore, vitiligo has been associated with defective recycling of tetrahydrobiopterin (6BH4), essential for melanin formation, leading to an excess of 7BH4 and inhibition of phenylalanine hydroxylase (PAH)

TRAF2 transiently induced at 0.51 h in both mice genotypes was re-expressed in WT at 36 and 4860 h after PH, whereas it was barely detectable at 40 and 60 h in mutant mice

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