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The detoxifying and antioxidant effects of Glutathione also help to protect our immune system

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W

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Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress

These factors continuously stimulate the TLR and purinergic receptors (such as P2X7) of surrounding cells, creating a positive feedback loop that allows inflammation to amplify and trigger systemic acute inflammation (108, 109)