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This mechanism could play a role in the development of DILI in individuals taking medications that produce drug-related neoantigens, triggering immune-mediated hepatic injury and compromising liver function [57] (Table 3)

Ascaris is a Clade III nematode that diverged from C

Cell Metab 17(2):261270 Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M et al (2016) On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

Advances in Interleukin-6 family cytokines and the role in respiratory diseases

These signaling cascades finally leads to phosphorylating and activating IKK complex which in turn phosphorylates IB exposing it to the proteasomal degradation, thus unmasking NF-B, permitting its nuclear translocation and eventually triggering the transcription of an assortment of pro-inflammatory genes [47]