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Based on this data, the authors supposed involvement of this protein in HaCaT cells carcinogenesis

Arshad, A

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Yusuf M

While swelling is necessary for proper wound healing, too much or prolonged swelling can impair healing and lead to chronic wounds

These results suggest that upon depletion of GSH, tissues undergo reprogramming to hyperactivate NRF2, possibly as a mechanism to upregulate adjacent antioxidant pathways and buffer oxidative stress induced upon GSH depletion