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After the treatment, the same volume of SDS-PAGE sample buffer was added, and the samples were analyzed by western blotting

Metabolite separation was executed through both reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC), with detection performed using a UHPLC-TOF/MS system (AB Sciex, 6600 + , Framingham, USA) in both positive and negative electrospray ionization modes

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Only randomized controlled trials (RCTs) were included and the meta-analysis was conducted according to PRISMA guidelines

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